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KMID : 0903520040470020283
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2004 Volume.47 No. 2 p.283 ~ p.286
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Antioxidative Effects of Polyozellin and Thelephoric Acid Isolated from Polyozellus multiflex
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Chung Shin-Kyo
Jeon So-Young
Lee Hee-Ju
Kim Suk-Kyung
Kim Sang-In
Kim Geum-Sook
Kwon Soon-Ho
Kim Ja-Young
Song Kyung-Sik
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Abstract
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In the course of screening for reactive oxygen species scavengers from natural products, two antioxidants were isolated from the edible mushroom Polyozellus multiflex and identified as polyozellin and thelephoric acid. Thelephoric acid inhibited 45.7% of the super oxide anion radical, 74.6% of the hydroxyl radical, and 44.0% of the DPPH radical at 0.1 mM, while the positive control α-tocopherol did 22.1%, 75.6%, and 26.5% of each radical, respectively. Polyozellin, the reductive acetylated form of thelephoric acid, showed almost same scavenging activity against above mentioned radicals. The isolated compounds showed scavenging activity on the superoxide anion radical in the ESR method (IC50 of polyozellin and thelephoric acid were 218.0 μM and 21.1 μM, respenctively). However, they showed no significant activity on the hydrogen peroxide radical.
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KEYWORD
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Polyozellus multiflex, reactive oxygen species scavenger, antioxidant, polyozellin, thelephoric acid
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